Enhanced antiscrapie effect using combination drug treatment.
نویسندگان
چکیده
Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 10 شماره
صفحات -
تاریخ انتشار 2006